The novel is a profound contemplation of life as seen through the eyes of two female protagonists: a 54-year-old concierge and a precocious 12-year-old girl, both living in the same upscale Parisian apartment building. The concierge, who conceals her intelligence and passion for literature and philosophy from the wealthy tenants, and the girl, who plans to commit suicide on her 13th birthday due to her disillusionment with the world, form an unlikely friendship. Their lives are forever changed when a wealthy Japanese man moves into the building.

The book is a compelling narrative that delves into the life and practice of a compassionate and unconventional French general practitioner. Through a series of vignettes and patient encounters, the novel explores the intricacies of the doctor-patient relationship, the challenges of the medical profession, and the ethical dilemmas faced by physicians. The protagonist's approach to medicine is deeply humanistic, focusing on the individual needs of his patients rather than strictly adhering to medical protocols. His dedication to his work and the personal stories of those he treats paint a vivid portrait of a small community and the pivotal role a caring doctor plays within it.

"Simple" is a touching narrative that delves into the life of a young man with cognitive disabilities, known by his nickname Simple, and his teenage brother who becomes his caretaker after they are orphaned. The story explores the challenges they face as they navigate a world that is often unkind and unaccommodating to those with special needs. With humor and warmth, the novel addresses themes of family, acceptance, and the societal perceptions of individuals with intellectual disabilities, while showcasing the deep bond between the siblings as they strive to create a life together against the odds.