The graphic novel follows the life of a slacker and part-time musician, Scott Pilgrim, who falls for an enigmatic American delivery girl named Ramona Flowers. However, to win her heart, Scott must defeat her seven evil exes in a series of surreal video game-inspired battles. Set in Toronto, Canada, the story combines elements of romance, comedy, and fantasy, as Scott navigates the complexities of relationships, self-identity, and adulthood, all while showcasing the unique visual style and cultural references that have made the series a cult favorite.

The book is a darkly comic, Western-inspired tale that follows the notorious sibling hitmen, Eli and Charlie Sisters, as they journey through the American frontier during the 1850s Gold Rush. Tasked with killing a prospector who has allegedly stolen from their employer, the brothers grapple with a series of increasingly bizarre and violent encounters. Along the way, Eli, the more introspective of the two, begins to question their life of crime and contemplates a different future, reflecting on themes of brotherhood, redemption, and the elusive nature of the American Dream.

The book is a memoir that blends fact with fiction, offering a comedic and surreal account of the life of a well-known comedian and former "Saturday Night Live" cast member. It delves into his upbringing in Canada, his rise to fame, and his experiences in the world of comedy, all while playing fast and loose with the truth. The narrative is filled with the author's trademark wit and deadpan humor, as he recounts stories of gambling, the pitfalls of celebrity, and his own unique perspective on life, often questioning the nature of storytelling and the reliability of memory itself.