The novel takes place in a post-apocalyptic world where a pandemic has turned many people into zombies, or "skels." The protagonist is a survivor who is part of a team tasked with clearing out the remaining skels in Zone One, the area in and around lower Manhattan. The story alternates between the present and the past, revealing the protagonist's experiences during the initial outbreak and his struggle to hold onto his humanity in the face of such devastation.

The novel explores the harsh life aboard the HSS Matilda, a spaceship organized much like the antebellum South, where the lower decks are populated by dark-skinned sharecroppers ruled by white overseers. The protagonist, a neurodivergent, queer black woman, serves as the ship's healer and navigates the oppressive social structure while uncovering the secrets of her mother's past and the ship's mysterious journey. Her search for truth leads to revelations that could alter the fate of the Matilda's segregated society, as she grapples with the complexities of identity, autonomy, and resistance against a backdrop of systemic injustice and intergenerational trauma.

In this science fiction novel, the protagonist, born in a world where travel between parallel universes is possible, is one of the rare individuals who can traverse these alternate realities due to her counterparts being dead in other worlds. The story delves into themes of identity, privilege, and survival, as she navigates complex relationships and a web of secrets. Her unique position allows her to gather intel across worlds, but it also places her in grave danger, leading her to confront her own past and the stark disparities between different versions of her life and society. As she moves through these spaces, she must grapple with the moral implications of her actions and the true meaning of having a place to call home.

The narrative unfolds through the lives of two siblings endowed with extraordinary powers, set against the backdrop of systemic racism and societal turmoil in America. The older brother's abilities emerge amidst the violence of the Los Angeles riots, while his younger sister's powers manifest as a form of telekinesis. As they navigate a world rife with injustice and the carceral state's oppressive reach, the siblings grapple with the potential and limitations of their gifts. The story is a searing exploration of anger, hope, and the indomitable spirit of resistance, examining whether supernatural abilities can be a catalyst for change in a world entrenched in institutionalized inequality.