The novel takes place in a post-apocalyptic world where a pandemic has turned many people into zombies, or "skels." The protagonist is a survivor who is part of a team tasked with clearing out the remaining skels in Zone One, the area in and around lower Manhattan. The story alternates between the present and the past, revealing the protagonist's experiences during the initial outbreak and his struggle to hold onto his humanity in the face of such devastation.

In the novel, a team of four women—an anthropologist, a surveyor, a psychologist, and a biologist—embark on an expedition into Area X, a mysterious and remote region cut off from civilization. The area is known for its strange occurrences and the disappearance of previous expedition members. As the team delves deeper into the wild and enigmatic landscape, they encounter bizarre creatures, cryptic signs, and the remnants of a lost civilization. The biologist, serving as the narrator, documents their discoveries and her own personal transformations, driven by the unseen forces of Area X. The novel explores themes of nature, mutation, and the unknown, as the expedition's members confront the limits of knowledge and the consequences of seeking to uncover the inexplicable.

In a post-apocalyptic world, an unseen terror drives society to madness and suicide upon sight, leading survivors to navigate their lives blindfolded. The story follows a mother who must guide her two young children to safety on a perilous river journey to what she hopes will be a sanctuary. With the ever-present threat of the unseen horrors and the challenges of survival in a collapsed society, the novel is a tense exploration of fear, the unknown, and the lengths one will go to protect their family.