"Good Omens" is a humorous take on the biblical Apocalypse, following an angel and a demon who have grown fond of Earth and its inhabitants, and are not too keen on the impending end of the world. As they try to locate the misplaced Antichrist and prevent the Four Horsemen from bringing about Armageddon, they encounter an array of quirky characters, including witch-hunters, modern-day witches, and the Four Horsemen themselves. The novel combines comedy, fantasy, and philosophical themes, offering a satirical critique of religious prophecy and human nature.

The book explores a fantastical journey where the narrator finds himself on a bus ride from a dreary, grey town to a beautiful, vibrant land that represents heaven. The passengers, who are ghostly figures, are given the opportunity to stay in this heavenly realm if they can let go of their earthly sins and attachments. Through a series of encounters with celestial beings and residents of this heavenly place, the story delves into themes of choice, redemption, and the nature of good and evil, ultimately illustrating the profound impact of personal decisions on one's eternal fate.

The book follows the journey of Dream, one of the Endless, who is captured and imprisoned by a group of occultists. After escaping decades later, Dream embarks on a quest to reclaim his lost artifacts of power, which are scattered across various realms and have fallen into the hands of both mortals and supernatural beings. As he retrieves these items, Dream encounters a range of characters, including John Constantine, Lucifer, and Doctor Destiny, each presenting unique challenges and insights into the nature of dreams and reality. The narrative weaves together themes of power, redemption, and the intricate tapestry of human and cosmic existence.