The novel is a reimagining of the Faust legend set in the context of the first half of the 20th century and the turmoil of Germany in that period. It tells the story of a composer who makes a pact with the devil, exchanging his soul for unlimited creative genius. The protagonist's life and work reflect the cultural and political journey of Germany leading up to World War II, providing a deep exploration of the individual's role in a society undergoing dramatic change. The novel is also a profound meditation on the nature of time, the art and the artist, and the destructiveness of human ambition.

Set in the 23rd century, the novel revolves around a highly intellectual game, the Glass Bead Game, which incorporates all fields of human and cosmic knowledge. The story follows the life of Joseph Knecht, a scholar who becomes a Magister Ludi (Master of the Game). The book explores his life and thoughts, including his relationships with others and his questioning of the values of his society. The narrative is a profound exploration of human life, knowledge, and spirituality.