A renowned Belgian detective finds himself embroiled in a complex murder case aboard the luxurious Orient Express train. The victim is a wealthy American businessman with numerous enemies, and the train's diverse passenger list includes individuals of varying nationalities and backgrounds, each with their own secrets. As the train is halted due to a snowdrift, the detective must race against time to solve the murder before the train reaches its destination and the murderer has a chance to escape.

The book is a classic espionage thriller that revolves around a crime novelist who becomes intrigued by the story of a notorious criminal, Dimitrios. The novelist's curiosity leads him on a journey across Europe, tracing the steps of Dimitrios, who is believed to be dead. As he delves deeper into Dimitrios's world of political intrigue, drug trafficking, and murder, he finds himself caught up in a dangerous game with life-threatening consequences.