Sisters Cassie and Allie leave Oregon to pursue acting in Los Angeles, but Allie becomes a star while Cassie remains stuck in bit parts. When Allie's body double is shot and Allie goes missing, police trace a last call to Cassie though she has no memory of placing it, and she is confined to a Portland psych ward amid public suspicion. Cassie checks out to find Allie, but macabre murders that mimic her family make her doubt everyone and herself.

A Harvard symbologist awakens in a Florentine hospital with no memory and finds himself thrust into a frantic international chase after a reclusive scientist obsessed with Dante, following a trail of art, architecture and cryptic puzzles drawn from the Divine Comedy; aided by a young physician, he races through Florence, Venice and Istanbul to decipher clues and stop a plot to release a bioengineered agent intended to address catastrophic population growth, all while confronting fraught ethical questions about sacrifice, security and the value of human life.

Emily Brand, a physicist, makes a major energy discovery and then disappears. Her research partner dies in a plane crash and a brutally ambitious oil executive, David Lucci, uses NARCON to prevent her from going public. He resorts to torture, blackmail, and murder to make her pay for what she did to him over twenty years ago.