Crumbling Genome by Alexey S. Kondrashov

The Impact of Deleterious Mutations on Humans

An evolutionary biologist argues that modern society’s relaxation of natural selection—through medicine, reduced child mortality, and changing reproductive patterns—is allowing harmful mutations to accumulate faster than they are removed, gradually lowering average biological fitness. Drawing on population genetics and genomic data, it explains mutation load, projects the potential consequences for health, cognition, and longevity, and evaluates possible responses, from expanded genetic screening and embryo selection to gene editing, while weighing the ethical and policy challenges of actively managing our genetic future.

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