Rigor Mortis by Richard Harris

How Sloppy Science Creates Worthless Cures, Crushes Hope, and Wastes Billions

A science journalist investigates the reproducibility crisis in biomedical research, revealing how flawed methods, perverse incentives, and sloppy lab practices generate unreliable findings and waste billions. Through case studies involving contaminated cell lines, questionable antibodies, and overhyped animal studies, it shows how systemic problems mislead scientists, patients, and policymakers. It also outlines reforms—such as better statistics, preregistration, reagent validation, and replication—to restore rigor and deliver treatments that genuinely help.

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