Dune Mesihi by Frank Herbert

Years after seizing power, Paul Atreides presides over an empire forged by a fanatical jihad fought in his name, but he is tormented by prescience, moral compromise, and the unintended consequences of absolute rule; as rival factions — including the Bene Gesserit, the Tleilaxu, the Spacing Guild, and disaffected nobles — plot against him, assassination, betrayal, and sacrifice force him to confront fate, responsibility, and the human cost of prophecy.